ω-Agatoxin IVA
Purity: ≥95%
Biological Activity
ω-Agatoxin IVA is a selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.Technical Data
(Modifications: Disulfide bridges: 4-20, 12-25, 19-36, 27-34)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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P-type calcium channels blocked by the spider toxin ω-Aga-IVA.
Mintz et al.
Nature, 1992;355:827 -
Calcium channels coupled to glutamate release identified by ω-Aga-IVA.
Turner et al.
Science, 1992;258:310 -
Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Bourinet et al.
Nat.Neurosci., 1999;2:407 -
Protease treatment of cerebellar purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA.
Tringham et al.
J.Pharmacol.Exp.Ther., 2008;324:806
Product Datasheets
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Citations for ω-Agatoxin IVA
The citations listed below are publications that use Tocris products. Selected citations for ω-Agatoxin IVA include:
6 Citations: Showing 1 - 6
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Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth.
Authors: Kim Et al.
Sci Rep 2018;8:7566
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Molecular basis of ancestral vertebrate electroreception.
Authors: Bellono
Nature 2017;543:391
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Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Authors: Medrihan Et al.
Nature 2013;4:1512
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The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
Authors: Jiang Et al.
Neuron 2010;66:248
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Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
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Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala.
Authors: Azad Et al.
Learn Mem 2008;15:143
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