W146

Catalog #: 3602
8 Citations Datasheet / COA / SDS

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3602/1

W146 | CAS No. 909725-61-7 | Sphingosine-1-phosphate Receptor Antagonists

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Description: Potent and selective S1P1 receptor antagonist

Alternative Names: ML 056

Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

Purity: ≥98%

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Product Details

Citations (8)

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Biological Activity

W146 is a potent sphingosine-1-phosphate receptor S1P₁ selective antagonist (K_i = 18 nM); displays no effect at S1P₂, S1P₃ or S1P₅. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data

M.Wt:

342.37

Formula:

C₁₆H₂₇N₂O₄P

Solubility:

Soluble to 20 mM in 3eq. NaOH

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

909725-61-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo.
Sanna et al.
Nat.Chem.Biol., 2006;8:434
Full pharmacological efficacy of a novel S1P₁ agonist that does not require S1P-like headgroup interactions.
Gonzalez-Cabrera et al.
Mol.Pharmacol., 2008;74:1308

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Citations for W146

The citations listed below are publications that use Tocris products. Selected citations for W146 include:

8 Citations: Showing 1 - 8

Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux.
Authors: Chen Et al.
Front Immunol 2023;14:1090202
Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
Authors: Richard M Et al.
Immunity 2022;55:254-271.e7
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Authors: Lucia Et al.
Arterioscler Thromb Vasc Biol 2021;41:e468-e479
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Authors: Huilan Et al.
Proc Natl Acad Sci U S A 2021;118
Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
Authors: Schuhmann Et al.
Mol Cell Biol 2015;16:29454
Fingolimod induces neuroprotective factors in human astrocytes.
Authors: Hoffmann Et al.
J Neuroinflammation 2015;12:184
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
Authors: Beckham Et al.
PLoS One 2013;8:e76593
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Authors: Beckham Et al.
Oncogenesis 2013;2:e49

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