W146

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3602/1
W146 | CAS No. 909725-61-7 | Sphingosine-1-phosphate Receptor Antagonists
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Description: Potent and selective S1P1 receptor antagonist
Alternative Names: ML 056

Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

Purity: ≥98%

Product Details
Citations (8)
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Biological Activity

W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data

M.Wt:
342.37
Formula:
C16H27N2O4P
Solubility:
Soluble to 20 mM in 3eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
909725-61-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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