WAY 181187 oxalate
Chemical Name: 1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate
Purity: ≥98%
Biological Activity
WAY 181187 oxalate is a high affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo.
Brouard et al.
ACS Chem.Neurosci., 2015;6:1241 -
Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist.
Cole et al.
J.Med.Chem., 2007;50:5535
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Citations for WAY 181187 oxalate
The citations listed below are publications that use Tocris products. Selected citations for WAY 181187 oxalate include:
2 Citations: Showing 1 - 2
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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.
Authors: David E Et al.
Cell 2022;185:3390-3407.e18
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Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
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