WEB 2086
Chemical Name: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
Purity: ≥99%
Biological Activity
WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice.
Wu, Haiya, Yang, Jun, Su, Emily M, Li, Ling, Zhao, Caiqi, Yang, Xi, Gao, Zhaowei, Pan, Mengyao, Sun, Peiyu, Sun, Wei, Jiang, Yiyi, Su, Xiao
PLoS ONE, 2014;9(3):e93003. -
Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086.
Dent et al.
FEBS Lett., 1989;244:365 -
Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats.
Sariahmetoglu et al.
Pharmacol.Res., 1998;38:173 -
Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.
Cellai et al.
Br.J.Cancer, 2006;94:1637
Product Datasheets
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Citations for WEB 2086
The citations listed below are publications that use Tocris products. Selected citations for WEB 2086 include:
6 Citations: Showing 1 - 6
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Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice.
Authors: Wu Et al.
PLoS One 2014;9:e93003
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A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.
Authors: Gabl Et al.
PLoS One 2014;9:e109516
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Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation.
Authors: Yagnik
Int J Inflam 2014;2014:526496
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Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.
Authors: Zhao Et al.
Br J Pharmacol 2013;8:e82683
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Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
Authors: Ajiro Et al.
PLoS One 2011;301:H2395
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Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids.
Authors: Al-Shawaf Et al.
Arterioscler Thromb Vasc Biol 2010;30:1453
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