WIN 18446

Tocris Bioscience | Catalog # 4736

ALDH1A2 inhibitor
Tocris Bioscience

Key Product Details

Description

ALDH1A2 inhibitor
View all Aldehyde Dehydrogenase Inhibitors »

Product Description

WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

Product Specifications for WIN 18446

Molecular Weight

366.11

Formula

C12H20Cl4N2O2

Storage

Store at +4°C

Chemical Name

N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)

CAS Number

1477-57-2

PubChem ID

15134

InChI Key

FAOMZVDZARKPFJ-UHFFFAOYSA-N

SMILES

ClC(Cl)C(NCCCCCCCCNC(C(Cl)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.61 100

Preparing Stock Solutions for WIN 18446

The following data is based on the product molecular weight 366.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.66 mL 27.31 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for WIN 18446

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for WIN 18446

For research use only

Customer Reviews for WIN 18446 (1)

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  • Effectively inhibits human Aldh1a2
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 09/13/2019
    Win-18446 showed an IC50 value at approximately 15 uM in a cell-free reaction assay. Was dissolved in DMSO to 100 mM with no solubility issues.
    This was used to inhibit recombinant Aldh1a2 activity in a titration curve.
    WIN 18446 4736

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