WM 1119
Chemical Name: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Purity: ≥98%
Biological Activity
WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Baell et al.
Nature., 2018;560:253
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for WM 1119
The citations listed below are publications that use Tocris products. Selected citations for WM 1119 include:
1 Citation: Showing 1 - 1
-
High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening.
Authors: Jun Et al.
Nat Commun 2020;11:3455
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for WM 1119
There are currently no reviews for this product. Be the first to review WM 1119 and earn rewards!
Have you used WM 1119?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
