Home / Histone Acetyltransferase Inhibitors / WM 3835

WM 3835

Catalog #: 7366
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7366/50
7366/10
WM 3835 | CAS No. 2229025-70-9 | Histone Acetyltransferase Inhibitors
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Description: Lysine acetyltransferase HBO1 (KAT7) inhibitor

Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. Reduces H3K14ac levels and inhibits growth and viability of acute myeloid leukemia cell lines in vitro. Cell-permeable.

Technical Data

M.Wt:
400.42
Formula:
C20H17FN2O4S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2229025-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. HBO1 is required for the maintenance of leukaemia stem cells.
    MacPherson et al.
    Nature, 2019;577:299

Product Datasheets

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Citation for WM 3835

The citations listed below are publications that use Tocris products. Selected citations for WM 3835 include:

1 Citation: Showing 1 - 1

  1. A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell leukemia.
    Authors: Lancho Et al.
    Blood Cancer Discov.  2023;4:12

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