Home / Formyl Peptide Receptor Antagonists / WRW4

WRW4

Catalog #: 2262
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2262/1
WRW4
1 Image
Description: Selective FPR2 antagonist
Alternative Names: WRW4

Purity: ≥95%

Product Details
Citations (9)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data

M.Wt:
1104.28
Formula:
C61H65N15O6
Sequence:
WRWWWW

(Modification: Trp-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
878557-55-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy
    R Gussenhove, L Klein, DRMG Ophelders, DHJ Habets, B Giebel, BW Kramer, LJ Schurgers, CPM Reutelings, TGAM Wolfs
    J Clin Med, 2019;8(2):.
  2. Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2
    A Gaudin, M Tolar, OA Peters
    Sci Rep, 2018;8(1):8921.
  3. Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling.
    Bae et al.
    J.Immunol., 2004;173:607
  4. Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4.
    Yunbo Ke, Noureddine Zebda, Olga Oskolkova, Taras Afonyushk, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov
    Circulation Research, 2017;0(0):1524-4571.
  5. Serum Amyloid A1 is an epithelial pro-restitutive factor
    BH Hinrichs, JD Matthews, D Siuda, MN O'Leary, AA Wolfarth, BJ Saeedi, A Nusrat, AS Neish
    Am. J. Pathol., 2018;0(0):.
  6. Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    T Kuzumoto, T Tanigawa, A Higashimor, H Kitamura, Y Nadatani, K Otani, S Fukunaga, S Hosomi, F Tanaka, N Kamata, Y Nagami, K Taira, T Watanabe, Y Fujiwara
    PLoS ONE, 2021;16(5):e0250862.
  7. The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors
    R Amagai, T Takahashi, H Terui, T Fujimura, K Yamasaki, S Aiba, Y Asano
    International Journal of Molecular Sciences, 2023;24(1):.

Product Datasheets

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Citations for WRW4

The citations listed below are publications that use Tocris products. Selected citations for WRW4 include:

9 Citations: Showing 1 - 9

  1. Neutrophils self-limit swarming to contain bacterial growth in vivo.
    Authors: Kienle Et al.
    Science  2021;372:1262
  2. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.
    Authors: Cussell Et al.
    PLoS One  2019;14:e0217815
  3. Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.
    Authors: Rhys Et al.
    EBioMedicine  2018;29:60
  4. Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome.
    Authors: Wenceslau Et al.
    Am J Physiol Heart Circ Physiol  2015;308:H768
  5. Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1.
    Authors: Hasan Et al.
    BMC Mol Biol  2014;18:497
  6. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection.
    Authors: Tristão Et al.
    Infect Immun  2013;81:1256
  7. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
    Authors: Barnig Et al.
    Sci Transl Med  2013;5:174ra26
  8. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest  2013;123:443
  9. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2.
    Authors: Khau Et al.
    Korean J Physiol Pharmacol  2011;25:483

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