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WS 12

Catalog #: 3040
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3040/10
3040/50
WS 12 | CAS No. 68489-09-8 | TRPM Agonists
1 Image
Description: TRPM8 agonist; cooling agent

Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

WS 12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).

Technical Data

M.Wt:
289.41
Formula:
C18H27NO2
Solubility:
Soluble to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
68489-09-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers
    GS Gunaratne, NA Yahya, PI Dosa, JS Marchant
    PLoS Negl Trop Dis, 2018;12(4):e0006420.
  2. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators.
    Beck et al.
    Cell Calcium, 2007;41:285
  3. Characterisation of TRPM8 as a pharmacophore receptor.
    Bodding et al.
    Cell Calcium, 2007;42:618

Product Datasheets

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Citations for WS 12

The citations listed below are publications that use Tocris products. Selected citations for WS 12 include:

2 Citations: Showing 1 - 2

  1. Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
    Authors: Morgan Et al.
    Biosci Rep  2015;35
  2. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
    Authors: Liu Et al.
    Pain  2013;154:2169

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