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WWL 113

Catalog #: 5259
1 Citation Datasheet / COA / SDS

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5259 has been discontinued.
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WWL 113 | CAS No. 947669-86-5 | Hydrolase Inhibitors
1 Image
Description: Ces3 and Ces1f inhibitor

Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

WWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

Technical Data

M.Wt:
466.53
Formula:
C29H26N2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
947669-86-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
    Dominguez et al.
    Nat.Chem.Biol., 2014;10:113

Product Datasheets

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Citation for WWL 113

The citations listed below are publications that use Tocris products. Selected citations for WWL 113 include:

1 Citation: Showing 1 - 1

  1. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
    Authors: Patra Et al.
    Nat Cell Biol  2018;20:811

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