Xamoterol hemifumarate
Chemical Name: 1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
Purity: ≥97%
Biological Activity
Xamoterol hemifumarate is a β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Role of AKAP79/150 protein in beta1-adrenergic receptor trafficking and signaling in mammalian cells.
Li X, Nooh M, Bahouth S
J Biol Chem, 2013;288(47):33797-812. -
β-Adrenoceptor stimulant properties of aminoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols.
Barlow et al.
J.Med.Chem., 1981;24:315 -
The in vitro pharmacology of xamoterol (ICI 118,587).
Malta et al.
Br.J.Pharmacol., 1985;85:179 -
The cardiovascular effects of ICI 118,587: a β1-adrenoceptor partial agonist.
Nuttall and Snow
Br.J.Pharmacol., 1982;77:381
Product Datasheets
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Citations for Xamoterol hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for Xamoterol hemifumarate include:
10 Citations: Showing 1 - 10
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Adrenergic modulation of AMPK-dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer.
Authors: Zhi Et al.
Int J Oncol 2019;54:1625
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Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.
Authors: Picard Et al.
Commun Biol 2018;1:106
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β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
Authors: Lavine
Invest Ophthalmol Vis Sci 2017;58(1):299
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β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
Authors: Creed Et al.
Breast Cancer Res 2015;17:145
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Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
Authors: Copik Et al.
J Pharmacol Exp Ther 2015;10:e0115701
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Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
Authors: Lavine Et al.
JAMA Ophthalmol 2013;131:376
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Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
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Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
Authors: Baker Et al.
FASEB J 2011;25:4486
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β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.
Authors: Steinle Et al.
PLoS One 2003;278:20681
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Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes.
Authors: Skeberdis Et al.
Br J Pharmacol 1997;121:1277
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