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YIL 781 hydrochloride

Catalog #: 3959
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3959/5
3959/25

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YIL 781 hydrochloride | CAS No. 1640226-17-0 | Ghrelin Receptor Antagonists
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Description: Ghrelin receptor (GHS-R1a) antagonist

Chemical Name: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

YIL 781 hydrochloride is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.

Technical Data

M.Wt:
445.96
Formula:
C24H28FN3O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1640226-17-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for YIL 781 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for YIL 781 hydrochloride include:

4 Citations: Showing 1 - 4

  1. Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs.
    Authors: Marc G Et al.
    ACS Pharmacol Transl Sci  2019;2:230-246
  2. Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.
    Authors: T?th Et al.
    Synapse  2018;72
  3. G Protein and β-arrestin signaling bias at the ghrelin receptor.
    Authors: Evron Et al.
    J Biol Chem  2014;289:33442
  4. Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion.
    Authors: Song Et al.
    PLoS One  2013;8:e65422

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