YKL 5-124

Key Product Details

Product Description

YKL-5-124 is a potent and selective CDK7/Mat1/CycH and cyclin dependent kinase (CDK7) inhibitor (IC₅₀ values = 9.7 nM and 53.5 nM, respectively). YKL-5-124 shows 100-fold selectivity over CDK9 and CDK2. YKL-5-124 induces cell cycle arrest at the G₁/S transition, inhibits E2F-driven gene expression and inhibits CDK1 and CDK3 T-loop phosphorylation.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for YKL 5-124

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YKL 5-124

The following data is based on the product molecular weight 515.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.70 mL	48.49 mL	96.97 mL
1 mM	1.94 mL	9.70 mL	19.39 mL
2 mM	0.97 mL	4.85 mL	9.70 mL
10 mM	0.19 mL	0.97 mL	1.94 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Olson Development of a selective CDK7 covalent inhibitor reveals predominant cell-cycle phenotype. Cell Chem.Biol. 2019 PMID: 30905681

Product Documents for YKL 5-124