Home / IAP Inhibitors / YM 155

YM 155

Catalog #: 6491
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6491/50
6491/10
YM 155 | CAS No. 781661-94-7 | IAP Inhibitors
1 Image
Description: Survivin suppressor
Alternative Names: sepantronium bromide

Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

Technical Data

M.Wt:
443.29
Formula:
C20H19BrN4O3
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
781661-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for YM 155

The citations listed below are publications that use Tocris products. Selected citations for YM 155 include:

2 Citations: Showing 1 - 2

  1. SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model.
    Authors: Serafini Et al.
    Sci.Signal.  2023;16:eade4984
  2. Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
    Authors: Eric Et al.
    Dev Cell  2019;49:393-408.e7

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for YM 155

There are currently no reviews for this product. Be the first to review YM 155 and earn rewards!

Have you used YM 155?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.