Zaprinast
Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Purity: ≥98%
Biological Activity
Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
Lugnier
Pharmacol.Ther., 2006;109:366 -
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
Taniguchi et al.
FEBS Lett., 2006;580:5003 -
Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
Christensen and Torphy
Annu.Rep.Med.Chem., 1994;29:185 -
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
Soderling et al.
J.Biol.Chem., 1998;273:15553
Product Datasheets
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Citations for Zaprinast
The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:
6 Citations: Showing 1 - 6
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Mitochondrial remodeling and ischemic protection by G protein�coupled receptor 35 agonists.
Authors: Wyant Et al.
Science 2022;377:621
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Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
Authors: Rojewska
Pharmacol Rep 2018;71:139
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The antiallergic mast cell stabilizers lodox. and bufrolin as the first high and equipotent agonists of human and rat GPR35.
Authors: MacKenzie Et al.
Mol Pharmacol 2014;85:91
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Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats.
Authors: Polcari Et al.
Proc Natl Acad Sci U S A 2013;27:338
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Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
Authors: Zerani Et al.
J Endourol 2004;183:279
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Assessing the emetic potential of PDE4 inhibitors in rats.
Authors: Robichaud Et al.
Br J Pharmacol 2002;135:113
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