Home / Additional Apoptosis-related Compounds / ZE 132

ZE 132

Catalog #: 7533 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7533/2
ZE 132 | CAS No. 2566710-63-0 | Additional Apoptosis-related Compounds
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Description: Potent and selective PD-1/PD-L1 interaction inhibitor

Chemical Name: 2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid

Purity: ≥98%

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Biological Activity

ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (KD = 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC50 = 23.49 nM). ZE 132 promotes CD8+ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.

Technical Data

M.Wt:
721.27
Formula:
C37H41ClN4O7S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2566710-63-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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