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ZZL 7

Catalog #: 7898 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7898/10
ZZL 7 | CAS No. 99141-91-0 | SLC6A4/5-HTTLPR
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Description: Inhibitor of SERT and nNOS interaction

Chemical Name: N-Acetyl-L-alanyl-L-valine methyl ester

Purity: ≥98%

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Biological Activity

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), reduces extracellular 5-HT concentration and downregulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 readily crosses the blood-brain barrier.

Technical Data

M.Wt:
244.29
Formula:
C11H20N2O4
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
99141-91-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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