Multiple Sclerosis and Myelin Related Molecules
Myelin is the insulating sheath that surrounds axons and facilitates rapid transmission of electrical signals between neurons. Myelin is composed of lipid, myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). Degeneration of the myelin sheath occurs during some auto-immune diseases, such as multiple sclerosis and acute disseminated encephalomyelitis.
- Attractin
- CDK5
- EVA1
- FoxP3
- Galactosylceramidase/GALC
- Galectin-1
- GATA-3
- GPR6
- IFN-gamma
- IL-1 beta/IL-1F2
- IL-2
- IL-4
- IL-6
- IL-10
- IL-12
- IL-17/IL-17A
- IL-17RA/IL-17R
- IL-18/IL-1F4
- IL-18/IL-18 BPa Complex
- IL-21
- IL-22
- IL-23
- IL-23R
- IL-27
- IL-33
- IL-6/IL-6R alpha Complex
- IL-6R alpha
- IL-Y (IL-12p40/IL-27p28)
- LAP (TGF-beta 1)
- MAG/Siglec-4a
- MBP
- MHC class II (I-A/I-E)
- MOG
- Myelin PLP
- Myeloperoxidase/MPO
- NF2/Merlin
- Nogo-A
- Nogo-B
- Nogo-C
- OMgp
- Oncomodulin
- PADI2
- PALS1/MPP5
- PSMA/FOLH1/NAALADase I
- RAR alpha/NR1B1
- RAR beta/NR1B2
- RAR gamma/NR1B3
- ROR gamma t/RORC2/NR1F3
- SMPD1
- Sphingosine Kinase 1/SPHK1
- Sphingosine Kinase 2/SPHK2
- T-bet/TBX21
- TGF-beta
- Thrombomodulin/BDCA-3
- TSLP
- TSPAN2
- TSPAN3
- VIGR/GPR126