DR6/TNFRSF21: Products

DR6, death receptor 6, is a typeI transmembrane protein that is a member of the TNF receptor superfamily (TNFRSF21). It is expressed in most human tissues. The highest levels of expression are in heart, brain, placenta, pancreas, thymus, and lymph node. The extracellular region of human DR6 is most closely related to OPG (42%) and TNFRII (36%). The cytoplasmic region is most related to TNFRI (27%).