TIAM1: Products

TIAM1 (T lymphoma invasion and metastasis) is an approximately 200 kDa member of the TIAM family of guanine-nucleotide exchange factors. It is expressed in multiple cell types, including endothelial cells, neurons, Schwann cells and almost all tumors. TIAM1 stimulates the activity of RHO-like GTPases and thus connects extracellular signals to the cytoskeleton. Human TIAM1 is 1591 amino acids (aa) in length. It contains a myristoylation site at Gly2, plus two pleckstrin homology domains (aa 434-549 and 1261-1397), a Ras-binding region (aa 765-832) and a RhoGEF/DH domain (aa 1041-1232). Over aa 1-378, human TIAM1 shows 94% aa identity to mouse TIAM1.