"NK cell" has 124 results in Resources.

Natural killer (NK) cells are innate lymphocytes that play a crucial role in the early response to infection or malignant transformation. Under these conditions, NK cells are activated and promote target cell death through the release of cytolytic granules. In addition, they secrete cytokines that regulate the functions of other immune cells. The activity of NK cells is controlled by the relative...

The innate immune system is made up of cells that might be considered "first responders" to a variety of microbial challenges. The cells are varied in type and participate both in an immediate, non-specific response to a foreign element and the development of a learned and remembered specific immune response.1,2 Among the cells traditionally considered "innate" are macrophages, mast cells,...

This brochure briefly describes the role that Natural Killer (NK) cells, and related receptors (NCR, NKG2, NKG2D, Nectin, Nectin like Binding Receptors, KIR) play in the immune system as well tools for NK research, including: Fluorochrome and unconjugated antibodies for a variety of applications NK cell selection kits Recombinant Proteins for NK cell research ELISAs and...

Jody Bonnevier, Nathan Downing, Sherry Lin, Joy Aho, Ernesto Resnik & Jessie Ni ABSTRACT We have developed new MagCellect™ kits for the isolation of untouched natural killer (NK) cells from both mouse and human preparations. The new kits achieve levels of purity as high as 95%. Undesired populations are negatively depleted using a cocktail of monoclonal antibodies that specifically react...

Isolate the cells you need for your adoptive cell transfer experiments with our Magcellect™ Cell Selection Kits. Using these kits, unwanted cells are magnetically tagged with a biotinylated antibody cocktail and streptavidin ferrofluid. The cell suspension is subsequently placed in a magnetic field, and the desired, untouched cell population of choice is harvested by aspiration and immediately...

Cancer ImmunotherapyResearch Products View Markersfor MDSCSubsets Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors, immature granulocytes, macrophages, and dendritic cells at different stages of differentiation. These cells are of great interest because they have the capacity to suppress both the cytotoxic activities of natural killer (NK)...

View the HumanNK Cell Activating& Inhibitory ReceptorsInteractive Pathway View Natural KillerCell Markers Natural killer cells (NK cells) are innate lymphoid cells that function as both cytotoxic effectors and regulators of immune responses. NK cells develop from common lymphoid progenitor cells primarily in the bone marrow and are educated to become self-tolerant by recognition of self MHC...

In the conventional model of hematopoiesis, multipotent hematopoietic stem cells (HSCs) self-renew and differentiate into two types of progenitor cells with specific lineage commitments. Like HSCs, human lineage-restricted progenitor cells also express CD34 and Flt-3/Flk-2. In human and mouse, common myeloid progenitors (CMPs) express IL-3 R alpha and give rise to cells of the myeloid lineage...