"ROR" has 29 results in Resources.

Antibody validation and specificity are not new headlines in the research community. Recent comparisons of R&D SystemsTM Human/Mouse ROR gamma t Recombinant Monoclonal Antibody (Clone # 1181A) to other ROR gamma t clones, demonstrate its superior performance. The data shown below suggest that a popular clone from another supplier is giving false negatives in mouse Th17-differentiated...

Featured Literature T Cell Subsets Poster View Poster Featured Products CD4+ T Cell Subsets Brochure View Brochure   Overview of Th17 Differentiation Pathways Upon TCR activation, naive CD4+ T cells differentiate into one of several T helper cell lineages depending primarily on cytokines present in the surrounding environment. Each T helper...

Flow cytometry is essential for the study of innate lymphoid cells (ILCs). It allows multiparameter analysis of cell populations based on the expression of specific cell surface and/or intracellular molecules. Consensus gating strategies were established in collaboration with researchers in the ILCs field.1,2 For ILC single cell suspension preparation, R&D systems scientists used...

The complexity of Wnt intracellular signaling pathways parallels the complexity observed in the diversity of Wnt receptors. Wnt receptors include the Frizzled family, Low Density Lipoprotein Receptor-related Proteins-5/6 (LRP-5/6), Receptor Tyrosine Kinase-like Orphan Receptor-1/2 (ROR1/2), and related to tyrosine (Y) kinase (Ryk). Frizzled receptors are seven transmembrane G protein-coupled...

Coordinate Receptor Family RTK/Control   Coordinate Receptor Family RTK/Control A1, A2 control PY-Control*   D1, D2 TIE Tie-2 A23, A24 control PY-Control*   D3, D3 NGFR TrkA B1, B2 EGFR EGF R   D5, D6 NGFR TrkB B3, B4 EGFR ErbB-2   D7,...

View NCR+ ILC3Cell Markers Natural cytotoxicity receptor (NCR)+ group 3 innate lymphoid cells (ILC3s), along with (NCR)- ILC3s are two phenotypically distinguishable subsets of ILC3s that have been characterized in mice and humans. In both species, ILC3s are involved in mediating the immune response against specific extracellular pathogens and maintaining tissue homeostasis at mucosal sites,...

View Th17 Differentiation Pathway T helper type 17 (Th17) cells are involved in the immune response mounted against specific fungi and extracellular bacteria. In mice, Th17 cells develop from naive CD4+ T cells in the presence of TGF-beta and IL-6. These cytokines induce the STAT3-dependent expression of IL-21, IL-23 R, and the transcription factor, ROR gamma t. IL-21 and IL-23...

Christine Goetz, Alberto Guerra, and Jody Bonnevier ABSTRACT Th17 cells are a subset of CD4+ T helper cells that play a crucial role in protection against extracellular bacteria, but may also be involved in autoimmune disease progression. Consequently, basic and clinical research on Th17 cells has increased tremendously in the last several years, becoming one of the most prominent and active...

Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of airway immunity, please view our poster Airway Inflammation in Asthma. Request Airway Inflammation in Asthma...

Human Phospho-RTK Array Kit Ordering Information Introduction R&D Systems™ Human Phospho-Receptor Tyrosine Kinase (RTK) Array Kit (Catalog # ARY001B) is a screening tool designed to simultaneously detect the relative phosphorylation of 49 different RTKs. This kit eliminates the need for numerous immunoprecipitation (IP) and/or Western blot experiments. RTKs are captured by antibodies...