"ikk*" has 14 results in Resources.

Click on the tabs below for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of atherosclerosis, please view our poster Atherosclerosis Disease Progression. Request Poster   Myeloid...

Featured Literature Chemokine Superfamily Poster View Poster   Overview of Chemokine Signaling Pathways Chemokines are a large family of small (typically 8-14 kDa), chemoattractant proteins that play a central role in controlling leukocyte migration during development, homeostasis, and inflammation. Following secretion, soluble chemokines or those localized to...

The IL-17 family of cytokines consists of six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by a number of different cell types and primarily promote pro-inflammatory immune responses. Cytokines belonging to the IL-17 family are secreted as dimers and bind to members of the IL-17 receptor family. The IL-17 receptor family includes IL-17 R/IL-17RA,...

There is great interest in identifying downstream T cell responses following immune checkpoint blockade to direct more effective treatments and better-informed therapeutic decisions. R&D Systems and Tocris offer a wide selection of reagents, kits, and assays that will allow you to explore, modulate, and validate T cell responses downstream of immune checkpoint blockade. Immune Checkpoint...

Request Mucosal Immunity of the Intestine Poster The intestinal lamina propria contains many types of myeloid and lymphoid cells that maintain tolerance or carry out inflammatory responses. Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study...

The major output of MAPK signaling downstream of inflammatory cytokines is a proinflammatory response. TNF Receptor (TNFR) activation by TNF superfamily ligands leads to recruitment of TRAF-2, TRAF-3, TRAF-6, and IKK gamma to the TNFR complex. TRAF-2 and TRAF-6 are subsequently auto-polyubiquitinated with Lys63-linked chains in a Ubc13-Uev1a-dependent manner. Ubiquitinated TRAF-2 and TRAF-6...

J. Rivard, A. James, G. Wegner, K. Reagan ABSTRACT In colonic epithelia, tumor necrosis factor alpha (TNF-alpha) secreted by inflammatory cells is a key mediator of inflammatory bowel disease. TNF-alpha is a well-characterized activator of the NF kappa B signaling pathway in intestinal epithelial cells and is known to upregulate the expression of a subset of chemokines and cytokines. In...

Featured Literature Inflammasomes: Intracellular Regulators of Pathogen Recognition, Host Defense, and Inflammation Poster View Poster Featured Products Pattern Recognition Receptors Brochure View Brochure   Overview of NOD-like Receptors Nucleotide-binding, oligomerization domain (NOD)-like receptors (NLRs) are a family of cytosolic...

C-type lectin receptors (CLRs) are a large family of soluble and transmembrane proteins that contain one or more distinct protein folds known as C-type lectin-like domains (CTLD). A small subset of these proteins has been categorized as pattern recognition receptors due to the fact that they are activated by specific pathogen- or damage-associated molecules and induce signaling pathways that...

The recent Zika virus outbreak has highlighted the need for more research into the mechanisms of virus entry, replication, and the antiviral immune response. Bio-Techne has the tools needed to advance our understanding of the Zika virus and other related viruses belonging to the Flaviviridae family, including yellow fever virus, dengue virus, West Nile virus, and Japanese encephalitis virus....