1400W dihydrochloride
Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride
Purity: ≥99%
Biological Activity
1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective activation of microglia facilitates synaptic strength.
Clark A, Gruber-Schoffnegger D, Drdla-Schutting R, Gerhold K, Malcangio M, Sandkuhler J
J Neurosci, 2015;35(11):4552-70. -
Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model
J Kuen, D Darowski, T Kluge, M Majety
PLoS ONE, 2017;12(7):e0182039. -
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo.
Garvey et al.
J.Biol.Chem., 1997;272:4959 -
Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury.
Parmentier et al.
Br.J.Pharmacol., 1999;127:546 -
Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.
Thomsen et al.
Cancer Res., 1997;57:3300
Product Datasheets
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Citations for 1400W dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 1400W dihydrochloride include:
9 Citations: Showing 1 - 9
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Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation.
Authors: M?ller Et al.
Front Immunol 2018;9:2520
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Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model
Authors: Staunton Et al.
Exp Physiol 2018;103:535
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Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model.
Authors: Kuen Et al.
PLoS One 2017;12:e0182039
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Selective activation of microglia facilitates synaptic strength.
Authors: Clark Et al.
RNA 2015;35:4552
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Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Authors: Gross Et al.
J Mol Cell Cardiol 2013;59:20
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Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents.
Authors: Gresa-Arribas Et al.
PLoS One 2012;7:e45227
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Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.
Authors: Al-Shalmani Et al.
Br J Pharmacol 2011;162:1485
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Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.
Authors: Tsuda Et al.
J Cell Mol Med 2009;13:3251
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Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature.
Authors: Ashrafpour Et al.
Am J Physiol Heart Circ Physiol 2004;286:H946
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