1400W dihydrochloride
Tocris Bioscience | Catalog # 1415
Product Description
1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.
Product Specifications for 1400W dihydrochloride
Molecular Weight
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Chemical Name
CAS Number
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.02 | 100 |
Preparing Stock Solutions for 1400W dihydrochloride
The following data is based on the product molecular weight 250.17.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.00 mL | 19.99 mL | 39.97 mL |
| 5 mM | 0.80 mL | 4.00 mL | 7.99 mL |
| 10 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.
- Putra Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model. Neurobiol.Dis. 2020 PMID: 30940499
- Staunton Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model. Exp.Physiol 2018 PMID: 29441689
- Parmentier Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br.J.Pharmacol. 1999 PMID: 10385257
- Thomsen Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 1997 PMID: 9242464
- Garvey 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J.Biol.Chem. 1997 PMID: 9030556
Product Documents for 1400W dihydrochloride
Product Specific Notices for 1400W dihydrochloride
For research use only
Related Research Areas
Citations for 1400W dihydrochloride
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Species: MouseAssay Type: In VitroCell Line/Tissue: primary BMDMVerified Customer | Posted 04/03/2021Macrophages were treated with LPS (10 ng/mL) and IFN-y (20 ng/mL) for 24h in the presence of 1400W (100 uM)
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Species: MouseAssay Type: In VitroCell Line/Tissue: MacrophagesVerified Customer | Posted 05/16/2019RAW macrophages were treated with 200 ng/ml LPS alone or after pre-treatment with 1 μM 1400W (30 min pre-incubation) for 8 h to follow iNOS expression using Western blot. LPS treatment elevated iNOS expression while 1400W pretreatment significantly blunted this effect.
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Species: MouseAssay Type: Ex VivoVerified Customer | Posted 07/28/2018Good solubility and stabilityUsed as iNOS inhibitor for organ bath experiments with rat and mouse aorta
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