Home / Histamine H4 Receptor Agonists / 4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride

Catalog #: 2342
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2342/10
2342/50
4-Methylhistamine dihydrochloride | CAS No. 36376-47-3 | Histamine H4 Receptor Agonists
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Description: Selective, high affinity H4 agonist

Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride

Product Details
Citations (4)
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Biological Activity

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data

M.Wt:
198.09
Formula:
C6H11N3.2HCl
Solubility:
Soluble to 50 mM in water
Storage:
Desiccate at RT
CAS No:
36376-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor.
    Glatzer F, Gschwandtner M, Ehling S, Rossbach K, Janik K, Klos A, Baumer W, Kietzmann M, Werfel T, Gutzmer R
    J Allergy Clin Immunol, 2013;132(6):1358-67.
  2. Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
    Lim et al.
    J.Pharmacol.Exp.Ther., 2005;314:1310
  3. Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.
    Gbahou et al.
    Br.J.Pharmacol, 2006;147:74

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Citations for 4-Methylhistamine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:

4 Citations: Showing 1 - 4

  1. Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
    Authors: Kim Et al.
    Korean J Physiol Pharmacol  2013;17:149
  2. Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
    Authors: Desmadryl Et al.
    Br J Pharmacol  2012;167:905
  3. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
    Authors: Connelly Et al.
    Br J Pharmacol  2009;157:55
  4. Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
    Authors: Holden Et al.
    Bone Joint Res  2007;152:891

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