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5-Fluorouracil

Catalog #: 3257
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3257/50
5-Fluorouracil | CAS No. 51-21-8 | Thymidylate Synthetase Inhibitor
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Description: Thymidylate synthetase inhibitor
Alternative Names: 5-FU

Chemical Name: 5-Fluoro-2,4-(1H,3H)-pyrimidinedione

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

5-Fluorouracil is an anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.

Technical Data

M.Wt:
130.08
Formula:
C4H3FN2O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
51-21-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs
    E Makino, V Gutmann, C Kosnopfel, H Niessner, A Forschner, C Garbe, T Sinnberg, B Schittek
    Cell Death Dis, 2018;9(9):930.
  2. Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture
    F Lorenzi, R Babaei-Jad, J Sheard, B Spencer-De, AS Nateri
    Mol Ther Methods Clin Dev, 2016;3(0):16024.
  3. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Robinson T, Liu J, Vizeacoumar F, Sun T, Maclean N, Egan S, Schimmer A, Datti A, Zacksenhaus E
    PLoS ONE, 2013;8(11):e78641.
  4. An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug.
    Ghoshal and Jacob
    Biochem.Pharmacol., 1997;53:1569
  5. Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
    Peters et al.
    Biochim.Biophys.Acta., 2002;1587:194
  6. 5-Fluorouracil: mechanisms of action and clinical strategies.
    Longley et al.
    Nat.Rev.Cancer, 2003;3:330

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⚠ WARNING: This product can expose you to chemicals including Fluorouracil, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for 5-Fluorouracil

The citations listed below are publications that use Tocris products. Selected citations for 5-Fluorouracil include:

2 Citations: Showing 1 - 2

  1. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
    Authors: Fukushima Et al.
    Cancer Sci  2015;106:1000
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

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