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7rh

Catalog #: 5860 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5860/5
7rh | CAS No. 1429617-90-2 | Additional RTK Inhibitors
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Description: Potent and selective DDR1 inhibitor; orally bioavailable

Chemical Name: 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

Purity: ≥98%

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Biological Activity

7rh is a potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

Technical Data

M.Wt:
546.59
Formula:
C30H29F3N6O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1429617-90-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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