ABT 702 hydrochloride
Chemical Name: 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride
Purity: ≥98%
Biological Activity
ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat.
Kowaluk et al.
J.Pharmacol.Exp.Ther., 2000;295:1165 -
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.
Lee et al.
J.Med.Chem., 2001;44:2133 -
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive
Jarvis et al.
J.Pharmacol.Exp.Ther., 2000;295:1156
Product Datasheets
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Citations for ABT 702 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ABT 702 hydrochloride include:
3 Citations: Showing 1 - 3
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Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965.
Authors: Ahwazi Et al.
Biochem J 2021;478:2977
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Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats.
Authors: Hobson Et al.
Neuropharmacology 2012;63:1172
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Adenosine kinase regulation of cardiomyocyte hypertrophy.
Authors: Fassett Et al.
Am J Physiol Heart Circ Physiol 2011;300:H1722
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