Acamprosate calcium

Name: Acamprosate calcium
Brand: Tocris Bioscience
SKU: 3618

Tocris Bioscience | Catalog # 3618

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Product Documents

GABA agonist; also glutamatergic modulator

Discontinued Product

3618 has been discontinued. View all GABA-A Receptor Agonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

GABA agonist; also glutamatergic modulator

Alternative Names

Calcium acetylhomotaurinate

View all GABA-A Receptor Agonists »

Product Description

Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.

Product Specifications for Acamprosate calcium

Molecular Weight

200.24

Formula

C₅H₁₀NO₄S.½ Ca

Storage

Desiccate at RT

Chemical Name

3-(Acetylamino)-1-propanesulfonic acid hemicalcium salt

CAS Number

77337-73-6

PubChem ID

155434

InChI Key

BUVGWDNTAWHSKI-UHFFFAOYSA-L

SMILES

CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	10.01	50

Preparing Stock Solutions for Acamprosate calcium

The following data is based on the product molecular weight 200.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	9.99 mL	49.94 mL	99.88 mL
2.5 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	1.00 mL	4.99 mL	9.99 mL
25 mM	0.20 mL	1.00 mL	2.00 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

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M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Berton Acamprosate enhances N-MthD.-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin.Exp.Res. 1998 PMID: 9514305
Popp and Lovinger Interaction of acampr. with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur.J.Pharmacol. 2000 PMID: 10771287
Spanagel Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur.J.Pharmacol. 1996 PMID: 8813529

Product Documents for Acamprosate calcium

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Product Specific Notices for Acamprosate calcium

For research use only

Related Research Areas

GABA Receptors

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