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Adapalene

Catalog #: 2852
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2852/10
2852/50
Adapalene | CAS No. 106685-40-9 | Retinoic Acid Receptor Agonists
1 Image
Description: RARβ and RARγ agonist
Alternative Names: CD 271,Differin

Chemical Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.

Technical Data

M.Wt:
412.52
Formula:
C28H28O3
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
106685-40-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. GSK3 is a regulator of RAR-mediated differentiation.
    Gupta K, Gulen F, Sun L
    Leukemia, 2012;26(6):1277-85.
  2. Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
    Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
    Biochem Biophys Res Commun, 2014;454(4):537-542.
  3. Adapalene: an update on newer comparative studies between the various retinoids.
    Millikan
    Int.J.Dermatol., 2000;39:784
  4. Pharmacology and chemistry of adap.
    Shroot et al.
    J.Am.Acad.Dermatol., 1997;36:S96
  5. The synthetic retinoid adap. inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.
    Ocker et al.
    Int.J.Cancer, 2003;107:453

Product Datasheets

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Citations for Adapalene

The citations listed below are publications that use Tocris products. Selected citations for Adapalene include:

2 Citations: Showing 1 - 2

  1. Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.
    Authors: Huk Et al.
    Arterioscler Thromb Vasc Biol  2013;33:285
  2. Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression.
    Authors: Dhandapani Et al.
    Drug Des Devel Ther  2011;71:5245

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