AG 556
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Purity: ≥99%
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM). Selective over ErbB2 (IC50 > 500 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit et al.
J.Med.Chem., 1991;34:1896 -
Secondary dimerization between members of the epidermal growth factor receptor family.
Gamett et al.
J.Biol.Chem., 1997;272:12052
Product Datasheets
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