AMP PNP
Chemical Name: Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
Purity: ≥90%
Biological Activity
AMP PNP is a non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel brain ATPase with properties expected for the fast axonal transport motor.
Brady
Nature, 1985;317:73 -
Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage.
Yount et al.
Biochemistry, 1971;10:2484 -
KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP.
Hehl and Neumcke
Eur.Biophys.J., 1994;23:231
Product Datasheets
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Citations for AMP PNP
The citations listed below are publications that use Tocris products. Selected citations for AMP PNP include:
2 Citations: Showing 1 - 2
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Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle.
Authors: Roland Et al.
Sci Adv 2021;7:eabk2392
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Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin.
Authors: Shimizu Et al.
Biochim.Biophys.Acta Biomembr. 2021;1864:183782
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