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API-1

Catalog #: 3897
5 Citations Datasheet / COA / SDS

Discontinued Product

3897 has been discontinued.
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API-1 | CAS No. 36707-00-3 | Akt (Protein Kinase B) Inhibitors
1 Image
Description: Selective Akt/PKB inhibitor. Antitumor

Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

Purity: ≥96%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

API-1 is an Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.

Technical Data

M.Wt:
337.29
Formula:
C13H15N5O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥96%
Storage:
Store at RT
CAS No:
36707-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for API-1

The citations listed below are publications that use Tocris products. Selected citations for API-1 include:

5 Citations: Showing 1 - 5

  1. The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases.
    Authors: Jezierska-Drutel Et al.
    BMC Cancer  2019;19:812
  2. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167).
    Authors: Arslan and Yerer
    Nutrients  2018;10
  3. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  4. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  5. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
    Authors: Zhu Et al.
    EMBO J  2012;31:31

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