ARN 726
Discontinued Product
Chemical Name: 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Purity: ≥98%
Biological Activity
ARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC50 values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation.
Ribeiro et al.
ACS Chem.Biol., 2015;10:1838 -
Activity-based probe for N-acylethanolamine acid amidase.
Romeo et al.
ACS Chem.Biol., 2015;10:2057 -
An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis.
Bonezzi et al.
J.Pharmacol.Exp.Ther., 2016;356:656
Product Datasheets
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