Home / 5-HT7 Receptor Agonists / AS 19

AS 19

Catalog #: 1968
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1968/10
1968/50
AS 19 | CAS No. 1000578-26-6 | 5-HT7 Receptor Agonists
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Description: Potent 5-HT7 agonist

Chemical Name: (2S)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

AS 19 is a potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo. AS 19 also promotes melanin synthesis in B16F10 murine melanoma cells.

Technical Data

M.Wt:
283.41
Formula:
C18H25N3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
1000578-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AS 19

The citations listed below are publications that use Tocris products. Selected citations for AS 19 include:

4 Citations: Showing 1 - 4

  1. Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways
    Authors: Tang Et al.
    FASEB J  2023;37:e22893
  2. Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.
    Authors: Dom?nguez-Soto
    Sci Rep  2017;7(1):14761
  3. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
    Authors: Majeed Et al.
    Neural Plast  2016;2016:7291438
  4. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Neuropsychopharmacology  2015;3:e00103

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