AY-NH2
Purity: ≥95%
Biological Activity
AY-NH2 is a selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.Technical Data
(Modifications: Phe-6 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
Hollenberg et al.
Br.J.Pharmacol., 2004;143:443 -
Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides.
Hollenberg and Saifeddine
Can.J.Physiol.Pharmacol., 2001;79:439 -
Structure-function analysis of protease-activated receptor 4 tethered ligand peptides.
Faruqi et al.
J.Biol.Chem., 2000;275:19728
Product Datasheets
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Citations for AY-NH2
The citations listed below are publications that use Tocris products. Selected citations for AY-NH2 include:
4 Citations: Showing 1 - 4
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Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange.
Authors: de la Fuente Et al.
Biochemistry 2020;59:671
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Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.
Authors: Peng Et al.
Front Immunol 2019;10:1311
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Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
Authors: Wang
Proc Natl Acad Sci U S A 2017;114(41):10948
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Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Oncogene 2015;21:4852
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