BX 513 hydrochloride
Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
Purity: ≥99%
Biological Activity
BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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RANTES-mediated control of excitatory amino acid release in mouse spinal cord.
Di Prisco S, Summa M, Chellakudam V, Rossi PI, Pittaluga A
J. Neurochem., 2012;121(3):428-37. -
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
Nat Commun, 2014;5(0):4715. -
Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor.
Hesselgesser et al.
J.Biol.Chem., 1998;273:15687 -
Discovery of a novel non-peptide CCR1 receptor antagonists.
Ng et al.
J.Med.Chem., 1999;42:4680 -
Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor.
Casarosa et al.
J.Biol.Chem., 2003;278:5172
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