BX 795
Chemical Name: N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Purity: ≥98%
Biological Activity
BX 795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and IκB kinase ε (IKKε). Also enhances lentiviral transduction of natural killer (NK) cells by around 3.8-fold.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
Feldman et al.
J.Biol.Chem., 2005;280:19867 -
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.
Sutlu et al.
Hum. Gene Ther., 2012;23:1090 -
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activati
Clark et al.
J.Biol.Chem., 2009;284:14136 -
Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Tamguney T, Zhang C, Fiedler D, Shokat K, Stokoe D
Exp. Cell Res., 2008-04-23;314(11):2299-312.
Product Datasheets
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Citations for BX 795
The citations listed below are publications that use Tocris products. Selected citations for BX 795 include:
3 Citations: Showing 1 - 3
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Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.
Authors: Anne Et al.
Nat Cell Biol 2021;23:704-717
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Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.
Authors: Johnson Et al.
Blood Adv 2019;3:198
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Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.
Authors: Pillai Et al.
Nat Commun 2015;6:10072
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