C16

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Small molecule inhibitors of the RNA-dependent protein kinase.
   Jammi et al.
   Biochem.Biophys.Res.Comm., 2003;308:50
2. The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation.
   Ingrand et al.
   FEBS Lett., 2007;581:4473
3. The specific PKR inhibitor C16 prevents apoptosis and IL-1� production in an acute excitotoxic rat model with a neuroinflammatory component.
   Tronel et al.
   Neurochem.Int., 2014;64:73
4. Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures.
   Couturier et al.
   J.Neuroinflammation, 2011;8

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