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Capzimin dimer

Catalog #: 6781 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6781/50
6781/10
Capzimin dimer | CAS No. 2084868-04-0 | Proteasome Inhibitors
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Description: Selective proteasome inhibitor

Chemical Name: 8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]

Purity: ≥98%

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Biological Activity

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.

Technical Data

M.Wt:
628.8
Formula:
C30H24N6O2S4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2084868-04-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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