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Caspase-9 Colorimetric Assay Kit

Catalog #: K119-100
45 Citations Datasheet / COA / SDS

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K119-100 has been discontinued.
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Citations (45)
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Caspase-9 Colorimetric Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-9

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
842 (Human)
Alternate Names
APAF-3APAF3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP9; CASP-9; caspase 9, apoptosis-related cysteine peptidase; Caspase9; Caspase-9; EC 3.4.22.62; ICE-LAP6CASPASE-9c; ICE-like apoptotic protease 6; MCH6apoptosis-related cysteine protease

Citations for Caspase-9 Colorimetric Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

45 Citations: Showing 1 - 10
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  1. Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
    Authors: TW Kim, HG Lee
    International Journal of Molecular Sciences, 2021-12-15;22(24):.  2021-12-15
  2. Aprepitant Promotes Caspase-Dependent Apoptotic Cell Death and G2/M Arrest through PI3K/Akt/NF-kappaB Axis in Cancer Stem-Like Esophageal Squamous Cell Carcinoma Spheres
    Authors: H Javid, AR Afshari, F Zahedi Avv, J Asadi, SI Hashemy
    BioMed Research International, 2021-12-09;2021(0):8808214.  2021-12-09
  3. Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells
    Authors: C Park, WS Lee, SI Go, SH Jeong, J Yoo, HJ Cha, YJ Lee, HS Kim, SH Leem, HJ Kim, GS Kim, SC Hong, YH Choi
    International Journal of Molecular Sciences, 2021-03-16;22(6):.  2021-03-16
  4. Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
    Authors: C Park, H Lee, JS Noh, CY Jin, GY Kim, JW Hyun, SH Leem, YH Choi
    Arch. Biochem. Biophys., 2020-07-24;691(0):108512.  2020-07-24
  5. Sensitivity of allyl isothiocyanate to induce apoptosis via ER stress and the mitochondrial pathway upon ROS production in colorectal adenocarcinoma cells
    Authors: JH Chiang, FJ Tsai, YM Hsu, MC Yin, HY Chiu, JS Yang
    Oncol. Rep., 2020-07-21;0(0):.  2020-07-21
  6. Potential effects of allyl isothiocyanate on inhibiting cellular proliferation and inducing apoptotic pathway in human cisplatin-resistant oral cancer cells
    Authors: PY Chang, FJ Tsai, DT Bau, YM Hsu, JS Yang, MG Tu, SL Chiang
    J. Formos. Med. Assoc., 2020-07-03;0(0):.  2020-07-03
  7. Evaluation of the Impact of Cisplatin on Variances in the Expression Pattern of Leptin-Related Genes in Endometrial Cancer Cells
    Authors: D D?bru?, R Kie?basi?s, BO Grabarek, D Boro?
    Int J Mol Sci, 2020-06-10;21(11):.  2020-06-10
  8. Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells
    Authors: C Park, HJ Cha, EO Choi, H Lee, H Hwang-Bo, SY Ji, MY Kim, SY Kim, SH Hong, J Cheong, GY Kim, SJ Yun, HJ Hwang, WJ Kim, YH Choi
    Cancers (Basel), 2019-10-04;11(10):.  2019-10-04
  9. High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells
    Authors: IJ Tsai, WC Lin, YH Yang, YL Tseng, YH Lin, CH Chou, YK Tsau
    Int J Mol Sci, 2019-09-10;20(18):.  2019-09-10
  10. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells
    Authors: MJ Kang, SY Kim, EB Kwon, YH Jo, MK Lee, HS Lee, DO Moon, MO Kim
    PLoS ONE, 2019-06-19;14(6):e0218659.  2019-06-19
  11. Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption
    Authors: JR Zhang, Q Lin, FQ Liang, T Xie
    Med. Sci. Monit., 2019-03-11;25(0):1848-1856.  2019-03-11
  12. Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)
    Authors: L Yan, C Xiong, P Xu, J Zhu, Z Yang, H Ren, Q Luo
    Carbohydr Polym, 2019-02-25;213(0):361-369.  2019-02-25
  13. Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes
    Authors: H Zhang, CF Xu, C Ren, TT Wu, N Dong, YM Yao
    Cell. Physiol. Biochem., 2018-11-19;51(1):452-469.  2018-11-19
  14. Camalexin Induces Apoptosis via the ROS-ER Stress-Mitochondrial Apoptosis Pathway in AML Cells
    Authors: Y Yang, G Wang, W Wu, S Yao, X Han, D He, J He, G Zheng, Y Zhao, Z Cai, R Yu
    Oxid Med Cell Longev, 2018-11-14;2018(0):7426950.  2018-11-14
  15. Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-sensitive K+ channels
    Authors: Y Son, K Kim, HR Cho
    Biochem. Biophys. Res. Commun., 2018-04-21;500(2):504-510.  2018-04-21
  16. Reactive oxygen species-dependent apoptosis induction by water extract ofCitrus unshiupeel in MDA-MB-231 human breast carcinoma cells
    Authors: MY Kim, EO Choi, H HwangBo, DH Kwon, KI Ahn, HJ Kim, SY Ji, SH Hong, JW Jeong, GY Kim, C Park, YH Choi
    Nutr Res Pract, 2018-03-21;12(2):129-134.  2018-03-21
  17. Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells
    Authors: L Zhang, H Chen, M Wang, X Song, F Ding, J Zhu, X Li
    Oncol Lett, 2018-03-14;15(5):7037-7045.  2018-03-14
  18. Protective Effects of Liquiritigenin against Citrinin-Triggered, Oxidative-Stress-Mediated Apoptosis and Disruption of Embryonic Development in Mouse Blastocysts
    Authors: CH Huang, WH Chan
    Int J Mol Sci, 2017-11-27;18(12):.  2017-11-27
  19. Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic ?-Cells
    Authors: AMTA Nahdi, A John, H Raza
    Oxid Med Cell Longev, 2017-08-06;2017(0):7054272.  2017-08-06
  20. In vitro assessment of anti-proliferative effect induced by ?-mangostin from Cratoxylum arborescens on HeLa cells
    Authors: AI El Habbash, N Mohd Hashi, MY Ibrahim, M Yahayu, FAE Omer, M Abd Rahman, N Nordin, GEC Lian
    PeerJ, 2017-07-21;5(0):e3460.  2017-07-21
  21. Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation
    Authors: CW Lee, FL Yen, HH Ko, SY Li, YC Chiang, MH Lee, MH Tsai, LF Hsu
    Int J Mol Sci, 2017-07-13;18(7):.  2017-07-13
  22. Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis
    Authors: KH Kang, MH Han, JW Jeong, C Park, SH Lee, HW Lee, SH Hong, YH Choi, SH Hong
    Oncol Lett, 2017-05-22;14(1):853-859.  2017-05-22
  23. Induction of apoptosis by ethanol extract of Evodia rutaecarpa in HeLa human cervical cancer cells via activation of AMP-activated protein kinase
    Authors: Seon Young Park
    Biosci Trends, 2016-11-27;0(0):.  2016-11-27
  24. Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
    Authors: C Xue, Y Chen, DN Hu, C Iacob, C Lu, Z Huang
    Oncol Lett, 2016-10-13;12(6):4813-4820.  2016-10-13
  25. Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway
    Authors: M Lin, S Tang, C Zhang, H Chen, W Huang, Y Liu, J Zhang
    Acta Pharm Sin B, 2016-07-30;7(1):59-64.  2016-07-30
  26. The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission
    J Cell Mol Med, 2016-07-22;0(0):.  2016-07-22
  27. Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli.
    Authors: Boeddeker S, Baston-Buest D, Fehm T, Kruessel J, Hess A
    PLoS ONE, 2015-04-01;10(4):e0121103.  2015-04-01
  28. Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.
    Authors: Yu P, Petrus M, Ju W, Zhang M, Conlon K, Nakagawa M, Maeda M, Bamford R, Waldmann T
    Leukemia, 2014-08-14;29(3):556-66.  2014-08-14
  29. Protective effect of Aframomum melegueta phenolics against CCl(4)-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition.
    Authors: El-Halawany A, El Dine R, El Sayed N, Hattori M
    Sci Rep, 2014-07-30;4(0):5880.  2014-07-30
  30. Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway.
    Authors: Peng S, Lee C, Hour M, Tsai S, Kuo D, Chen F, Shieh P, Yang J
    Int J Oncol, 2013-11-14;44(1):238-46.  2013-11-14
  31. Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions.
    Authors: Ichihara A, Wang Z, Jinnin M, Izuno Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H
    J Allergy Clin Immunol, 2013-11-01;133(4):1065-74.  2013-11-01
  32. Soy soluble polysaccharide induces apoptosis in HCT116 human colon cancer cells via reactive oxygen species generation.
    Authors: Ko Y, Jeong J, Choi Y, Ryu C
    Mol Med Rep, 2013-10-14;8(6):1767-72.  2013-10-14
  33. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
    Authors: Han B, You B, Park W
    Oncol Rep, 2013-09-20;30(6):2999-3005.  2013-09-20
  34. Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair.
    Authors: Barckhausen C, Roos W, Naumann S, Kaina B
    Oncogene, 2013-04-22;33(15):1964-74.  2013-04-22
  35. The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
    Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
    Mol Med Rep, 2013-03-05;7(5):1539-44.  2013-03-05
  36. Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.
    Authors: Ehteda, Anahid, Galettis, Peter, Pillai, Krishna, Morris, David L
    BMC Cancer, 2013-02-23;13(0):86.  2013-02-23
  37. Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt.
    Authors: Han MH, Lee WS, Lu JN
    Int. J. Oncol., 2012-02-01;40(6):2090-6.  2012-02-01
  38. Antimitochondrial autoantibodies in pemphigus vulgaris: a missing link in disease pathophysiology.
    Authors: Marchenko S, Chernyavsky AI, Arredondo J, Gindi V, Grando SA
    J. Biol. Chem., 2009-12-10;285(6):3695-704.  2009-12-10
  39. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
    Authors: Cailleteau C, Liagre B, Beneytout JL
    J. Cell. Biochem., 2009-07-01;107(4):785-96.  2009-07-01
  40. Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25.
    Authors: Chen J, Zhang M, Ju W, Waldmann TA
    Blood, 2008-10-23;113(6):1287-93.  2008-10-23
  41. Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
    Authors: Tsai WS, Yeow WS, Chua A, Reddy RM, Nguyen DM, Schrump DS
    Mol. Cancer Ther., 2006-12-01;5(12):2977-90.  2006-12-01
  42. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck.
    Authors: Masood R, Kumar SR, Sinha UK, Crowe DL, Krasnoperov V, Reddy RK, Zozulya S, Singh J, Xia G, Broek D, Schonthal AH, Gill PS
    Int. J. Cancer, 2006-09-15;119(6):1236-48.  2006-09-15
  43. Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
    Authors: Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
    Circulation, 2004-09-14;110(11):II194-9.  2004-09-14
  44. Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease.
    Authors: Tanaka M, Nakae S, Terry RD, Mokhtari GK, Gunawan F, Balsam LB, Kaneda H, Kofidis T, Tsao PS, Robbins RC
    Blood, 2004-07-27;104(12):3789-96.  2004-07-27
  45. Apaf-1 is a mediator of E2F-1-induced apoptosis.
    Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
    J. Biol. Chem., 2002-07-30;277(42):39760-8.  2002-07-30

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