Home / Oxidative Phosphorylation Uncouplers / CCCP

CCCP

Catalog #: 0452
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0452/500
CCCP | CAS No. 555-60-2 | Oxidative Phosphorylation Uncouplers
1 Image
Description: Oxidative phosphorylation uncoupler

Chemical Name: Carbonyl cyanide 3-chlorophenylhydrazone

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CCCP is a protonophore. It disrupts mitochondria membrane potential by transporting protons across the mitochondrial inner membrane, which interferes with the proton gradient and ATP synthesis. CCCP is a widely used as an uncoupler of oxidative phosphorylation to induce mitochondrial depolarization.

Technical Data

M.Wt:
204.62
Formula:
C9H5ClN4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
555-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Increased mitochondrial ROS generation mediates the loss of PVAT anticontractile effect in HFD-treated obese mice
    Rafael Menezes da Costa
    Br. J. Pharmacol, 2016;0(0):.
  2. A new class of uncoupling agents - carbonyl cyanide phenylhydrazones.
    Heytler and Pritchard
    Biochem.Biophys.Res.Commun., 1962;7:272

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Citations for CCCP

The citations listed below are publications that use Tocris products. Selected citations for CCCP include:

4 Citations: Showing 1 - 4

  1. Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways.
    Authors: Guo Et al.
    Curr Protoc Chem Biol  2015;7:141
  2. Efavirenz induces neuronal autophagy and mitochondrial alterations.
    Authors: Purnell
    J Pharmacol Exp Ther  2014;351:250
  3. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
    Authors: Choubey Et al.
    Autophagy  2014;10:1105
  4. Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ.
    Authors: Chouhan Et al.
    J Neurosci  2010;30:1869

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CCCP

There are currently no reviews for this product. Be the first to review CCCP and earn rewards!

Have you used CCCP?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.