CD 3254
Chemical Name: 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
Purity: ≥97%
Biological Activity
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. CD 3254 can promote chemical reprogramming of mouse fibroblasts. In a fast chemical reprogramming protocol, it promotes reprogramming of foetal mouse dorsal fibroblasts (MDFs) and adult mouse lung fibroblasts (MLFs) to iPS cells within 12 days.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
Le Maire et al.
EMBO Rep., 2009;10:367 -
Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
Pogenberg et al.
J.Biol.Chem., 2005;280:1625
Product Datasheets
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Citation for CD 3254
The citations listed below are publications that use Tocris products. Selected citations for CD 3254 include:
1 Citation: Showing 1 - 1
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Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Authors: Wang Et al.
J Mol Cell Biol 2017;9:338
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