Celecoxib
Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Purity: ≥99%
Biological Activity
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Celecoxib is an anti-inflammatory with shorter plasma half-life in vivo than SC 58121. Displays chemopreventive activity in in vivo tumor models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
Autophagy, 2017;0(0):0. -
Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways
Lipids Health Dis, 2016;15(1):213. -
Lipoxin B4 Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression
N Kim, KL Lannan, TH Thatcher, SJ Pollock, CF Woeller, RP Phipps
J. Immunol., 2018;0(0):.
Product Datasheets
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Citations for Celecoxib
The citations listed below are publications that use Tocris products. Selected citations for Celecoxib include:
4 Citations: Showing 1 - 4
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Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
Authors: Christopher J Et al.
Cancer Res 2022;82:3375-3393
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Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug.
Authors: Cesare Et al.
Front Cell Dev Biol 2020;8:561179
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CXB Is Associated With Dystrophic Calcification and Aortic Valve Stenosis.
Authors: Bowler Et al.
JACC Basic Transl Sci 2019;4:135
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The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Authors: Oguh-Olayinka Et al.
Pathol Oncol Res 2019;
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