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CM 11

Catalog #: 6416 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6416/5
CM 11 | CAS No. 2244684-49-7 | Active Degraders
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Description: Homo-PROTAC® for self-degradation of pVHL30

Chemical Name: N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide

Purity: ≥98%

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Biological Activity

CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

E3 ligase
VHL
DC50
10-100 nM - Degradation of pVHL30 in HeLa cells after 24 h treatment
Selectivity confirmed by global proteomics
No
M.Wt:
1179.46
Formula:
C58H82N8O14S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2244684-49-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under licence from the University of Dundee

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