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CW 008

Catalog #: 5495
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5495/10
5495/50
CW 008 | CAS No. 1134613-19-6 | Protein Kinase A Activators
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Description: PKA signaling activator; promotes osteogenesis from hMSCs

Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.

Technical Data

M.Wt:
420.37
Formula:
C21H14F2N6O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1134613-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for CW 008

The citations listed below are publications that use Tocris products. Selected citations for CW 008 include:

4 Citations: Showing 1 - 4

  1. Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis.
    Authors: Xun Et al.
    Theranostics  2023;13:1247-1263
  2. Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins.
    Authors: Karen E Et al.
    Elife  2023;12
  3. A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells.
    Authors: Yong Et al.
    Toxicol Mech Methods  2021;31:393-399
  4. Bisphenol S enhances gap junction intercellular communication in ovarian theca cells.
    Authors: Yong Et al.
    Chemosphere  2021;263:128304

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