Cynomolgus Monkey OX40 (XP_005545179) VersaClone cDNA

Name: Cynomolgus Monkey OX40 (XP_005545179) VersaClone cDNA
Brand: R&D Systems
SKU: RDC1697
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC1697

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Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Cynomolgus Monkey

Accession Number

XP_005545179

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: OX40

OX40 (CD134; TNFRSF4) is a T cell costimulatory molecule of the TNF receptor superfamily that coordinates with other costimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is upregulated on antigen activated CD4+ and CD8+ T cells with costimulation by CD40-CD40 Ligand and CD28-B7. OX40 interactions with OX40 Ligand on antigen presenting cells enhances T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs where it promotes Treg proliferation and immunosuppressive activity. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease, and autoimmune disease.