[D-Phe12,Leu14]-Bombesin
Biological Activity
[D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.Technical Data
(Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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[d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists.
Heinz-Erian et al.
Am.J.Physiol., 1987;252:G439 -
(d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists.
Merali et al.
Synapse, 1988;2:282 -
Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake.
Flynn
Physiol.Behav., 1997;62:791
Product Datasheets
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