Delavirdine mesylate

Key Product Details

Product Description

Delavirdine mesylate is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC₅₀ values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.

Licensing Information

Sold for research purposes under agreement from Viiv.

Product Specifications for Delavirdine mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Delavirdine mesylate

The following data is based on the product molecular weight 552.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.41 mL	12.06 mL	24.13 mL
3.75 mM	0.48 mL	2.41 mL	4.83 mL
7.5 mM	0.24 mL	1.21 mL	2.41 mL
37.5 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Pagano and Chong In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha. J.Infect.Dis. 1995 PMID: 7528253
• Dueweke U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 1993 PMID: 7685995

Product Documents for Delavirdine mesylate