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DREADD agonist 21

Catalog #: 5548
5 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5548/10
5548/50
DREADD agonist 21 | CAS No. 56296-18-5 | DREADD Activators
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Description: Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Alternative Names: Compound 21,C21

Chemical Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Purity: ≥98%

Product Details
Citations (5)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DREADD agonist 21 is a potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits > 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo. Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).

Technical Data

M.Wt:
278.35
Formula:
C17H18N4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
56296-18-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DREADD agonist 21

The citations listed below are publications that use Tocris products. Selected citations for DREADD agonist 21 include:

5 Citations: Showing 1 - 5

  1. Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice.
    Authors: Peng Et al.
    J Clin Invest  2023;133
  2. The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis.
    Authors: Streamson Et al.
    J Clin Invest  2023;133
  3. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior.
    Authors: James P Et al.
    Elife  2020;9
  4. Amygdala inhibitory neurons as loci for translation in emotional memories.
    Authors: Nathaniel Et al.
    Nature  2020;586:407-411
  5. DREADDS: Use and application in behavioral neuroscience.
    Authors: Smith Et al.
    Behav Neurosci  2016;130:137

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Used in place of CNO
By Anonymous on 12/01/2017

Used this product in place of CNO

Used in place of CNO 5548
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